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Page last updated: December 2024

This section provides information on the research currently being conducted or facilitated by the UCD Cancer Trials Cluster. 

To learn more about clinical trial processes, see our 'What is Clinical Research' and our 'FAQs' pages. 

If you are interested in finding out more about the trials on offer, you can consult the associated link for each trial below. We strongly recommend that you discuss any potential study opportunity with your oncology or haematology medical team. For most of the studies below, we accept referrals nationally.

Enrollment on studies must be made through referrals by your oncology medical team.

Please contact (opens in a new window)cancertrials@ucd.ie with queries. 

Key terms used below:

Allied Health & Supportive Care Trial

A study in which a non-drug intervention is provided, usually to improve a person's quality of life

Medicinal Trial

Clinical trial for the investigation of a new medical product, including drugs, gene therapy, immunotherapy, or anaesthetics.

MMUH

The Mater Misericordiae University Hospital
Observational Study Research that collects data through observation, including surveys, interviews, prospective, patient registries, etc. For observational studies, there is no invervention component.  

Placebo

A placebo is an inactive treatment that looks and feels like a real one. It has no active ingredients that can change your health. It’s used in some research studies to compare it with the real treatment and see which one works better. Placebos help researchers know if the real treatment is effective or not.

SVUH

St Vincent's University Hospital

Translational Study

A research study based in a lab that explores the mechanisms of a disease. This type of research is important in developing better treatments and understanding of the disease. 

Open Studies

Basket studies are research studies/trial that include multiple different cancer types. The current portfolio of UCD Cancer Trials Cluster basket studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
ASTER ANT 007 Compare abelacimab against apixaban for  venous thromboembolism recurrence and bleeding Cancer related venous thromboembolism recieving cancer treatment currently or in past six months MMUH (opens in a new window)Click here Medicinal trial Open
MK-7339-002 / LYNK-002 Study of Olaparib effectiveness and safety People with previously treated advanced cancer with either a) homologous recombination repair mutation (HRRm) or b) homologous recombination deficiency (HRD) SVUH (opens in a new window)Click here Medicinal Trial Closed
Palliative care and Oncology Survey on Terminology (POST) Examine what individuals known to palliative care and oncology services think about the terminology used to describe them.  People with cancer, availing of inpatient or outpatients.  SVUH (opens in a new window)Click here Observational Study Open
PRAME-Immunocore  First-in-human study of the safety and efficacy of IMC-F106C on its own and in combination with checkpointinhibitors HLA-A*02:01 positive, PRAME positive tumor who have relapsed from or are intolerant of standard therapy SVUH (opens in a new window)Click here Medicinal trial Open
RS18-032  Pre-clinical study on the combination of immune checkpoint inhibitors and monoclonal antibody therapies NA SVUH NA Translational Study Open
Sleepio Study This study will examine the efficacy of digital cognitive behavioural therapy for insomnia (dCBT-I) compared to sleep hygiene education in treating symptoms of insomnia Women over the age of 18 with a current or prior cancer diagnosis who have clinical insomnia MMUH & SVUH (opens in a new window)Click here Allied Health & Supportive Care Trial Closing soon
SWAN (Sleep Well at Night) A multi-faceted intervetion to address sleep difficulties.  People with advanced cancer. SVUH Click here Observational Study Open
TPAC / Taste Changes An investigation into taste problems associated with xerostomia (dry mouth) in patients with advanced cancer. Any locally advanced or metastatic cancer with taste problems. SVUH NA Observational Study Open
WAYFIND-R Understand the natural history of solid tumour cancers  People profiled with a next generation sequencing test SVUH (opens in a new window)Click here Observational Study Open

For details of all basket studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Breast cancer studies are research studies/trial targeted towards breast cancers, such as invasive lobular breast cancer, triple negative breast cancer, or HER2 positive breast cancer. The current portfolio of UCD Cancer Trials Cluster breast studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
CAMBRIA-2 To compare the effectiveness and safety of camizestrant (AZD9833), a new oral medication that targets estrogen receptors, with standard hormone therapies. Early-stage breast cancer that is hormone receptor-positive and HER2-negative, and who have a higher risk of cancer returning. SVUH (opens in a new window)Click here Medicinal Trial Opening Soon
Destiny 15 Evaluate the effectiveness of Trastuzumab Deruxtecan (T-DXd) in delaying disease progression.  People with HER2-low or HER2 HER2 Immunohistochemistry (IHC) 0 breast cancer, whose disease is untreatable by surgery or is metastatic.  MMUH + SVUH (opens in a new window)Click here Medicinal Trial Opening Soon
EPIK-B5 To compare a drug called alpelisib in combination with another drug called fulvestrant in treating advanced breast cancer. Participants in placebo group who show signs of progression will be able to access the non-placebo drug. HR-positive, HER2-negative advanced breast cancer (men and post-menopausal women) with a PIK3CA mutation who progressed or relapsed on or after treatment with an AI plus a CDK4/6 inhibitor. SVUH (opens in a new window)Click here Medicinal Trial Open
J2J-MC-JZLH / Ember 4  Study of adjuvant imlunestrant vs standard adjuvant endocrine therapy  Previously received 2 to 5 years of adjuvant endocrine therapy for ER+, HER2- early breast cancer with an increased risk of recurrence SVUH (opens in a new window)Click here Medicinal Trial Open
MK-2870-010  To compare the effectiveness of the drug MK-2870 (alone or combined with Pembrolizumab) against standard treatment of physician’s choice. People with HR+/HER2-  advanced or metastatic breast cancer, which cannot be removed with surgery.  SVUH & MMUH (opens in a new window)Click here Medicinal Trial

MMUH: Open

SVUH: Opening Soon
MK-2870-012 To compare the efficacy and safety of a) adjuvant MK-2870 plus Pembrolizumab against b) treatment of physician’s choice. People with Triple-Negative Breast Cancer who received neoadjuvant therapy that was not fully effective.   SVUH (opens in a new window)Click here Medicinal Trial Open
Ovarian Escape To determine how common is 'ovarian escape' in women recieving ovarian function supression Premenopausal women receiving ovarian function suppression and endocrine therapy for early-stage and metastatic hormone receptor- positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer SVUH & MMUH NA Translational study Open
Shamrock To examine the effectiveness of the drug trastuzumab deruxtecan (T-DXd)  People with HER2-positive breast cancer (stage 2 or 3) SVUH (opens in a new window)Click here Medicinal trial On hold
SIGNATURE Study To explore the potential use of exosomes, isolated from the blood of patients diagnosed with TNBC (triple negative breast cancer), as a personal biomarker for the individual. People with triple negative breast cancer SVUH N/A Translational Study Open

For details of all breast cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Central nervous system studies address cancers of the brain and spinal cord. The UCD Cancer Trials Cluster does not currently conduct studies of central nervous system cancers. However, please refer to our list of 'basket studies' which may be relevant. 

For details of all central nervous system studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Gastrointestinal studies are research studies/trial of cancers located in the digestive system, such as the oesaphagus, liver, pancreas, stomach, intestine, bowel, rectum, and anus.

The current portfolio of UCD Cancer Trials Cluster gastrointestinal studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
DP-IMRT An early phase trial (Phase I/ II) to determine the appropriate dosage of radiotherapy. Resectable or borderline resectablepancreaticadenocarcinoma SVUH (opens in a new window)Click here Medicinal Trial Open
FEED Evaluate a 12-week nutritional care package consisting of diet, supplements, daily step target and dietitian and physiotherapist appointments.  People undergoing standard chemotherapy for pancreatic cancer SVUH (opens in a new window)Click here Allied Health & Supportive Care Trial Open
Mountaineer 03 (SGNTUC 029) Comparison of Tucatinib + Trastuzumab + mFOLFOX6 against mFOLFOX6 alone or with cetuximab or bevacizumab.  HER2+ metastatic colorectal cancer who have not received any previous systemic anti-cancer therapy. MMUH & Mater Private, & SVUH (opens in a new window)Click here Medicinal Trial Open
PaTcH 20-27 This study is designed to investigate the means by which treatment-resistent pancreatic cancer can be overcome by a combination of an established anticancer drug, trametinib, with hydroxychloroquine. People with advanced metastatic pancreatic adenocarcinoma or poorly differentiated pancreatic adenocarcinoma.  MMUH & SVUH (opens in a new window)Click here Medicinal Trial Open
ProvIDHe (DIM-95031-002) An open-label early access phase 3b study of Ivosidenib to consolidate its safety and effectiveness. Previously treated, locally advanced, or metastatic cholangiocarcinoma (CCA) SVUH (opens in a new window)Click here Medicinal Trial Open

For details of all gastrointestinal studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Gastrointestinal studies are research studies/trial of cancers located in the urinary tract or male genitals, such as the kidney, bladder, prostate, or testicles.

The current portfolio of UCD Cancer Trials Cluster genitourinary studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
IRONMAN Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men with Advanced Prostate Cancer/ IRONMAN Men with Metastatic Hormone Sensitive Prostate Cancer (mHSPC), Castration Resistant Prostate Cancer (CRPC), and men with prostate cancer who have mixed histological types. SVUH (opens in a new window)Click here Observational Study Open
MK-5684-003 To compare 'MK-5684' with hormone replacement therapy (HRT), to alternative abiraterone acetate or enzalutamide. Metastatic Castration-Resistant Prostate Cancer, Prostatic Neoplasms. SVUH (opens in a new window)Click here Medicinal Trial Open
MK-5684-004 Compare the drug 'MK-5684' to Alternative Abiraterone Acetate or Enzalutamide  People with metastatic castration-resistant prostate Cancer (mCRPC) who have progressed on/after previous treatment. SVUH (opens in a new window)Click here Medicinal Trial Open
MK-5684-01A (sub study) To evaluate the safety and effectiveness of MK-5684, either on its own or in combination with other treatments. Metastatic castration resistant prostate cancer. SVUH (opens in a new window)Click here Medicinal Trial Open
MoonRise 1 Compare the disease-free survival between participants receiving treatment with TAR-210 versus investigator's choice of chemotherapy delivered by catheter.  People with intermediate-risk non-muscle invasive bladder cancer and specific FGFR (fibroblast growth factor receptor) changes. MMUH, Mater Private, & SVUH (opens in a new window)Click here Medicinal Trial Opening soon
PEACE-6 Vulnerable Compare the effectiveness and safety of a combination treatment called androgen deprivation therapy (ADT) with or without darolutamide in frail men who have recently been diagnosed with advanced prostate cancer. Men with prostate cancer whose cancer has recently become metastatic. SVUH & MMUH, and Mater Private (opens in a new window)Click here Medicinal Trial Open

For details of all genitourinary studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Gynaecological studies are research studies/trial of cancers located in the female reproductive organs, such as the ovaries, uterus, cervix, vagina, and vulva. 

The current portfolio of UCD Cancer Trials Cluster gynaecology studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
MK-2870-005  To compare the effectiveness and safetey of the new drug MK-2870 with  physician’s choice of treatment  People with endometrial cancer who have received  platinum-based chemotherapy and immunotherapy previously MMUH (opens in a new window)Click here Medicinal Trial Open
MK-2870-020  Study of the drug MK2870 compared with an investigator's choice of chemotherapy  Second line recurrent or metastatic cervical cancer  MMUH TBC Medicinal Trial Open
ReFrame

Evaluate the efficacy and safety of Luveltamab Tazevibulin compared with investigator’s choice (IC) of chemotherapy 

 Women with relapsed platinum-resistant epithelial ovarian cancer (Including Fallopian Tube or Primary Peritoneal Cancers) that express Folate Receptor Alpha (FOLR1)  MMUH (opens in a new window)Click here Medicinal Trial Opening soon

For details of all gynaecological studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Head and neck cancer studies address cancers of the head and neck region, including the mouth and throat. The UCD Cancer Trials Cluster does not currently conduct studies of head and neck cancers. However, please refer to our list of 'basket studies' which may be relevant. 

For details of all head and neck studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Lung studies are research studies/trial targeted towards lung cancers, such as small cell lung cancer, non-small cell lung cancer, etc. The current portfolio of UCD Cancer Trials Cluster lung studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
NeoCOAST-2 To study the effect of different combinations of drugs, like Durvalumab, Oleclumab, Monalizumab, AZD0171, and others are safe and effective around the time of surgery.  Non-Small Cell Lung Cancer where surgery is a treatment option.  MMUH (opens in a new window)Click here Medicinal Trial Paused

For details of all lung studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Lymphoma and blood cancers studies are research studies/trials of cancers of the blood stream and immune system, such as leukaemia, myeloma, and myelodysplastic syndromes.

The current portfolio of UCD Cancer Trials Cluster lymphoma and blood cancer studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
Celgene ACE 536 MF 002 (INDEPENDENCE) Evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia People with Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions MMUH (opens in a new window)Click here Medicinal Trial Open
INCMOR 208-305 To evaluate the safety and efficacy of Tafasitamab plus Lenalidomide  People with relapsed or refractory diffuse large B-cell lymphoma MMUH (opens in a new window)Click here Medicinal Trial Open
Isa-RVD This study aims to evaluate the stringent Complete Response (sCR) rate by the end of two cycles of induction treatment, defined as the proportion of patients who have achieved sCR, according to International Myeloma Working Group (IMWG) criteria, by the end of two cycles of induction treatment. People with multiple myeloma who have received no prior treatment with any systemic therapy. MMUH (opens in a new window)Click here Medicinal Trial Open
LOXO 20022 / / BRUIN CLL-322 A trial of Pirtobrutinib (LOXO-305) plus Venetoclax and Rituximab (PVR) compared to Venetoclax and Rituximab (VR) only People with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322) who have recieved at least one previous treatment MMUH (opens in a new window)Click here Medicinal Trial Open
MajesTEC-4 Compare the effectiveness of Teclistamab combined with Lenalidomide versus the drugs administered on their own.  People with newly diagnosed multiple myeloma as maintenance therapy following stem cell transplant.  SVUH (opens in a new window)Click here Medicinal Trial Opening soon
MOSAICC The MOSAICC study (MyelOproliferative neoplasmS: An In-depth Case-Control) aims to identify what causes myeloproliferative neoplasms (MPNs) and the best way to improve patients’ quality of life.  People with a diagnosis of myeloproliferative neoplasms (MPNs)  SVUH and MMUH (opens in a new window)Click here Observational study Opening Soon

For details of all lymphoma and blood cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Paediatric cancer studies are research studies/trials that affect children, adolescents, and young adults. 

Name Purpose For People with Our location More Info Study Type Status
CabOSTar (CLIN-60000-461)  To assess the a) efficacy, b) safety, and c) how the body processes the drug (pharmacokinetics) of maintenance cabozantinib (XL184) plus best supportive care (BSC). This is compared to just BSC. Children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment. SVUH (opens in a new window)Click here Medicinal Trial Opening Soon

For details of all paediatric studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Sarcoma studies are research studies/trial of cancers that start in the bones and soft tissues of the body. The current portfolio of UCD Cancer Trials Cluster sarcoma studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
CabOSTar (CLIN-60000-461)  To assess the a) efficacy, b) safety, and c) how the body processes the drug (pharmacokinetics) of maintenance cabozantinib (XL184) plus best supportive care (BSC). This is compared to just BSC. Children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment. SVUH (opens in a new window)Click here Medicinal Trial Opening Soon
Median-Ph2 INBRX-109 This Phase 2 study is testing a treatment called INBRX-109 for conventional chondrosarcoma. The study will compare the effectiveness of INBRX-109 to a placebo in patients at any stage of treatment. People with conventional chondrosarcoma, unresectable (inoperable) or metastatic SVUH (opens in a new window)Click here Medicinal Trial Open

For details of all sarcoma studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Skin cancers are cancers that affect the skin, such as melanoma, squamous cell carcinoma, and basal cell carcinomas. 

The current portfolio of UCD Cancer Trials Cluster skin cancer studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
MelMart  A randomised trial to determine the safety and effectiveness of using a 1cm margian versus a 2cm when removing a melanoma.  People with an invasive cutaneous melanoma MMUH (opens in a new window)Click here Surgical trial Open
Regeneron R3767-ONC-2011 The primary objective of the study is to assess if Fianlimab + Cemiplimab is superior to Pembrolizumab in treating melanoma, as measured by progression-free survival (PFS) Patients with advanced melanoma that cannot be surgically removed (Stage III or Stage IV) SVUH (opens in a new window)Click here Medicinal Trial Open
Regeneron R3767-Onc-2055 A phase 3 trial of Fianlimab (Anti-LAG-3) and Cemiplimab versus Pembrolizumab in the adjuvant setting in patients with completely resected high-risk melanoma Patients with a melanoma that has been surgically removed within the previous 12 weeks. SVUH (opens in a new window)Click here Medicinal Trial Open

For details of all skin cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Contact the UCD Cancer Trials Cluster

UCD Clinical Research Centre, St Vincent's University Hospital, Elm Park, Dublin 4
E: cancertrials@ucd.ie