Charles Institute Seminar Series 2024-25: "Clinical and Mechanistic Research on Diabetic Wound Healing" Guest Speaker Professor Wuquan Deng
Date of Talk: Thursday, November 7th, 2024 @ 11 AM
Location: In Person & Online Via Zoom
Talk Title: Clinical and Mechanistic Research on Diabetic Wound Healing
Speaker Details: Professor Wuquan Deng
Professor of Endocrinology and Metabolism, Chongqing University Central Hospital, China
Short Biography:
Dr. Wuquan Deng is a Professor and Deputy Dean of Endocrinology and Chongqing University affiliated Central Hospital. His research team focuses on the pathogenesis of diabetes and its complications, alongside the development and translational application of advanced diagnostic and therapeutic technologies. Specifically, the team investigates the molecular mechanisms by which platelet-rich plasma and its derivatives—such as exosomes and nanovesicles—facilitate the healing of diabetic ulcers. Recently, they analyzed how the contents of platelet exosomes, including miR-26b, miR-132, and S1P, can inhibit wound inflammation and promote angiogenesis. Their ongoing efforts include modifying platelet derivatives to effectively target and regulate wound healing processes, as well as
actively conducting clinical trials of platelet exosomes to enhance their clinical applicability.
Abstract for talk:
The molecular mechanisms platelet-rich plasma and its derivatives—such as exosomes and nanovesicles—facilitate the healing of diabetic wound. Clinical application study on autologous, allogene PRP for patients with diabetic foot. The contents of platelet-derived exosomes promote diabetic wound healing through three aspects: promoting proliferation (study one), enhancing angiogenesis (study
two), and inhibiting wound inflammation (study three). Improving the modification of platelet-derived membrane vesicles to effectively target and regulate the wound healing process and actively conducting clinical trials of platelet-derived exosomes to enhance their clinical applicability.