Project Title: Melanocyte behavior in chronic plaque psoriasis: modeling of melanocyte proliferation and apoptosis during disease progression and remission for insights into the control of melanoma
Thematic Area: Inflammatory Skin Diseases
Focus of Research: Psoriasis
Overview:The Project aims to assess how the massive keratinocyte hyperplasia in plaque psoriasis affects proliferation in typically proliferation-resistant melanocytes, and how the induction of keratinocyte apoptosis in regressing lesions impacts on expanded melanocyte numbers to restore epidermal-melanin unit balance.
Funded by: UCD Start-Up funds.
PI: Prof Desmond J Tobin
Other Group/team members: Ms. Sarah Lussoso, Prof Brian Kirby.
Project Duration: January 2020- January 2024