Project Title: Chronic wound repair via cell-free delivery of tailored ADSC-derived exosomes using an injectable hydrogel through polarizing M2 macrophages
Thematic Area: Wound Healing & Wound Care
Focus of Research: Acute Wounds and Chronic Wounds
Overview:
A self-perpetuating inflammatory stage with an increase in inflammatory cells and proinflammatory cytokines hinders orchestrated skin wound repair in chronic wounds.Macrophages, a key regulator of tissue repair, undergo a unique phenotype shift from a proinflammatory phenotype at the early stage to anti-inflammatory or pro-healing phenotype later. Therefore, manipulating the proper balance between the two phenotypes is critical for appropriate wound healing.
The Aim of this project is to develop a degradable and injectable hydrogel dressing with the controllable release of tailored exosomes, derived from ADSCs, which can correct the disturbances in macrophage phenotype and the sustained inflammation state, ultimately promoting chronic wound healing".
Funded by: Government of Ireland Postdoctoral Fellowship
PI: Dr Qian Xu, Prof Wenxin Wang
Other Group/team members: -
Project Duration: October 2019- September 2021