Chemical Biophysics
Ian Mercer
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Address |
Dr Ian Mercer, Belfield, |
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Telephone: |
00 353 (1) 716 2226 |
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Email: |
ian.mercer@ucd.ie |
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Research centre: |
Synthesis & Chemical Biology |
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RESEARCH:
Ways are required to investigate
the influence of environment on signalling events and pathways, and to do so in
the live cell without altering processes being watched. A programme is being
initiated to advance and combine: a) multi-dimensional optical methods for both
the temporal and spatial unravelling of live cell signalling and; b) quantum
molecular-optical simulation for the interpretation of measurement and more
rational future design.
Cell signalling is the molecular mechanism whereby cells detect and respond to
external stimuli and send messages to other cells. Improved understanding of
cell signalling will lead to improved understanding of disease and the design
of new pharmaceuticals.
EXPERIENCE:
Quantum Mechanical/Molecular Mechanical combined
linear and nonlinear optical response protocols for simulation of large
solvated enzymes and biomolecules; investigation of
large solvated biomolecules through nonlinear
photonics and laser development; resolution and contrast enhanced x-ray
bio-imaging; next generation industrial lithography through advance in laser
driven sources; nanomaterials; advanced laser
development for industrial materials processing.
ACHIEVEMENTS
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Present |
UCD ( |
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2000 to 2003 |
Powerlase Ltd ( |
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2000 |
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1999 to 2001 |
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1997 to 1999 |
LLNL (CA,
US). Advanced laser development for industrial materials processing. PI and
Team Leader. |
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1995 to 1997 |
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1994-1995 |
Lund
Institute of Technology ( |
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1992-1994 |
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PUBLICATIONS:
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World
wide patent publications: 6, current and maintained (1999 to present).
Laser-photonics solutions. |
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Effect of
adiabaticity on electron dynamics in zinc myoglobin, B.M. Cho, R.C.Walker, H. Amer, I. Mercer,
D.R. Klug, I.R. Gould, J Phys Chem
B 109, 12, 5954-5961 (2005). ‘Industrial
Application of Lasers’, Encyclopedia of Modern
Optics, Ian P. Mercer, Encyclopedia of Modern
Optics, edited by Robert D. Guenther, Duncan G. Steel and Leopold Bayvel, Elsevier, Oxford, ISBN 0-12-227600-0 (2004). ‘Large
and fast relaxations inside a protein: Calculation and measurement of
reorganization energies in alcohol dehydrogenase’, R.C. Walker, M.M. de Souza, I.P. Mercer,
I.R. Gould, D.R. Klug, Journal of Physical
Chemistry B, Vol.106, No.44, 11658 (2002). ‘EUV
light source and laser considerations for scalability and high-energy
conversion efficiency’, I.P. Mercer et.al., Proc. SPIE Vol.
4760, 463-473 (2002). ‘Modulation
of the rate of electron injection in dye-sensitized nanocrystalline
TiO2 films by externally applied bias’, Y. Tachibana, S.A. Haque, I.P. Mercer, J.E. Moser, D.R. Klug,
J.R. Durrant, Journal of Physical Chemistry B, Vol.105, No.31, 7424 (2001). ‘Electron
injection and recombination in dye sensitised nanocrystalline
titanium dioxide films: a comparison of ruthenium bipyridyl
and porphyrin sensitiser
dyes’, Y.Tachibana,
S.A.Haque, I.P.Mercer, J.R.Durrant and D.R.Klug, J.Phys.Chem.B, Vol. 104, No.6, 1198 (2000). ‘A
Quantum Mechanical/Molecular Mechanical approach to solvation
dynamics: calculation of the optical properties of solvated Bacteriochlorophyll-a’, I.P.Mercer,
I.R.Gould, D.R.Klug, J.Phys.Chem.B, Vol. 103, No.36, 7720 (1999). ‘A Quantum Mechanical/Molecular
Mechanical Approach to Solvation Dynamics Tested by
Three Pulse Photon Echo Measurements’, Ian P. Mercer, Stefan Abend, Ian R. Gould, David R. Klug,
Springer Series in Chemical Physics
63, 532 (1998). ‘Survival
of mammalian cells exposed to ultrahigh dose-rates from a laser-produced
plasma X-ray source’, C.Tillman, G.Grafstrom, A.Jonsson, B.Jonsson, I.Mercer, S.Mattsson, S.Strand and S. Svanberg, Radiology, Vol. 213, No.3, 860 (1999). ‘The
excitation wavelength and solvent dependence of the kinetics of electron
injection in Ru(dcbpy)(2)(NCS)(2)
sensitized nanocrystalline TiO2 films’, J.R.
Durrant, Y. Tachibana, I. Mercer, J.E. Moser, M. Gratzel,
D.R. Klug, International Journal of Research in
Physical Chemsitry and Chemical Physics, Vol.212,
93, Part 1 (1999) “Frequency-resolved
time-gated high-order harmonics”, C.Altucci,
C. Delfin, M.B.Gaarde, A.L’Huillier, I.Mercer, T.Starczewski and C.-G. Walstrom,
Phys. Rev. A, Vol 58, No. 5, 3934 (1998). “5-20 keV laser-induced x-ray generation at 1 kHz from a
liquid-jet target”, R.J.Tompkins, I.P.Mercer, M.Fettweis, C.J.Barnett, D.R.Klug, L.G.Porter, I.Clark, S.Jackson, P.Matousek, A.W.Parker, M.Towrie, Review of
Scientific Instruments, Vol. 69, No.9, 3113 (1998). “The
control of the spatial mode of higher-order harmonics”, E.Mevel,
I. Mercer, R. Zerne, A.L’Huillier,
P. Antoine, C.G.Wahlstrom, Annales
de Physique, v.22 (sci), 73 (1997). “Optical
properties of solvated molecules calculated by a QMMM method: Chlorophyll-a and Bacteriochlorophyll-a”, I.P.Mercer, I.R.Gould, D.R.Klug, Philosophical Transactions: Mathematical,
Physical and Engineering Sciences, No. 1736 (1997) and Faraday Discussions
Vol. 108, 51 (1997). “Spatial
Mode Control of High-Order Harmonics”, I.Mercer, E.Mevel, R.Zerne, A.L’Huillier, P.Antoine, C.G.Wahlstrom, Phys. Rev. Lett.,
Vol. 77, No. 9, 1731 (1996). “X_ray Generation for Medical Applications from a
Laser-produced Plasma”, M.Gratz, C.Tillman, I.Mercer, S.Svanberg, Applied Surface Science, Vol. 96-98, 443
(1996). “Elemental
Biological Imaging by Differential Absorption Using a Laser-Produced X-ray
Source”, C.Tillman, I.Mercer,
S.Svanberg, K.Herrlin, J.
Opt. Soc. Am. B, Vol.13, No.1, 209 (1996). “Double-side
Pumped Ti:sapphire Regenerative Pre-amplifier
Operating at 1.053nm Wavelength”, F.Zhou, I.P.Mercer, M.H.R.Hutchinson, C.N.Danson, C.B.Edwards, Elec. Lett, Vol. 31, No. 13, 1060 (1995). “Harmonic
Generation from Solid-Vacuum Interface Irradiated at High Laser Intensities”,
S.Kohlweyer, G.D. Tsakiris,
C.G.Wahlstrom, C.Tillman,
I.Mercer, Opt. Comm., Vol. 117, 431 - 438 (1995). “Amplification
of XUV Harmonic Radiation in a Gallium Amplifier”, T.Ditmire,
M.H.R.Hutchinson, M.Key, C.L.Lewis, A.Macphee, I.Mercer, D.Neely, M.Perry, R.Smith, J.Wark and M.Zepf , Phys. Rev.
A. Vol. 51, R4337 (1995). "Diode-Pumped
Picosecond Nd:YLF Laser
Oscillator at 1053 nm", I.P.Mercer, Z.Chang, C.N.Danson, C.B.Edwards, M.H.R. Hutchinson, M.R.G.Miller,
Op. Comm., Vol. 107, No. 1-2, 77 - 82 (1994). ''High
Contrast multi-terawatt pulse generation using chirped pulse amplification on
the VULCAN laser facility'', C.N.Danson, L.Barzanti, Z.Chang, A. Damerell, C.B.Edwards, S.Hancock, M.H.R.Hutchinson, M.H.Key, S.Luan, R.Mahadeo, I.P.Mercer, P.Norreys, D.A.Pepler, D.A.Rodkiss, I.N.Ross, M.A.Smith, R.A.Smith, P.F.Taday, W.T.Toner, K.Wigmore, T.B.Winstone, R.W.Wyatt and F.Zhou, Opt. Comm., Vol. 103, No. 5-6, 392 - 397 (1993). |