AI_PREMie
The AI PREMie team, led by (opens in a new window)Professor Patricia Maguire from UCD School of Biomolecular and Biomedical Science, has been awarded €500,000 in recognition of the potential impact of their AI-powered risk stratification platform for preeclampsia. Also from the UCD ConwaySPHERE research group, the team includes Consultant Obstetrician and Gynaecologist (opens in a new window)Professor Mary Higgins and Consultant Haematologist and Full Clinical Professor Fionnuala Ní Áinle, UCD School of Medicine, and Dr Paulina Szklanna, UCD School of Biomolecular and Biomedical Science.
Preeclampsia (PET) is a condition of pregnancy that is difficult to diagnose and kills 50,000 mothers and 500,000 babies globally every year. At present delivery of the pre-term baby is the only treatment and the safest option for the mother. But pre-term delivery can lead to long-term neurodevelopmental problems and even death. ConwaySPHERE is working to develop a new diagnostic test called AI PREMie to better predict PET severity and help save the lives of both mothers and their babies. It is a risk stratification tool that identifies women with PET - and also how the condition will progress. Our AI PREMie tool assesses the pre-eclampsia risk based on circulating biomarkers in the plasma of pregnant mothers. This will give clinicians and other caregivers the opportunity to proactively plan pregnancies for at-risk mothers, giving a clearer understanding if planning for delivery is necessary or if the baby can stay in utero allowing for further development as every day in utero counts.
AI_PREMie Timeline
2017
Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early-onset preeclampsia.
Early onset preeclampsia (EOP) is a pregnancy-specific proinflammatory disorder that is characterised by competing thrombotic and bleeding risks. It was the aim of this study to characterise thrombin generation, a major determinant of thrombotic and bleeding risk, in order to better understand the haemostatic balance in patients with EOP.
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2018
CAPE Study Results
Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria.
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Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.
Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterize PR; with debated content and significant inter-individual variability reported, confident, and reliable insights have been hindered. Using label-free quantitative (LFQ)-proteomics analysis, a reproducible, quantifiable investigation of the 1U mL−1 thrombin-induced PR from 32 healthy adults was conducted.
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The Hundred-Person Platelet Releasate Project.
Upon activation platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, wound healing, tissue regeneration, inflammation, and pathologic sequelae.
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2019
(opens in a new window)Science Foundation Ireland Future Innovator Prize
AI for Societal Good Challenge
Supports interdisciplinary teams to develop novel, potentially disruptive AI-based solutions that address significant national and global societal challenges
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(opens in a new window)The platelet releasate in pregnancy and early-onset preeclampsia.
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2020
(opens in a new window)Irish Tech news article
(opens in a new window)Article in Roller coaster
SAS Viya join the AI-PREMie team
2021
(opens in a new window)Winner of the NovaUCD Innovation of the Year Award 2021
(opens in a new window)Siliconrepublic article
(opens in a new window)Runner up SFI Future Innovator Artificial Intelligence (AI) for Societal Goo
(opens in a new window)Finalist of Analytics Institute Social Impact Award.
(opens in a new window)"Using platelets as little health sensors in our blood" - The Irish Times
(opens in a new window)"Using platelets as little health sensors in our blood" - Recruitment for Technology
(opens in a new window)Engineers Ireland Article
(opens in a new window)the pan Canadian thrombotic Research Network
(opens in a new window)the iPlacenta H2020 virtual conference
(opens in a new window)Teck Expert Article
(opens in a new window)Geant Article
(opens in a new window)HEAnet Article
(opens in a new window)Science Direct Article
(opens in a new window)University Observer Interview
(opens in a new window)AI_PREMie in 2021 AI_Awards Finalists
(opens in a new window)International Society on Thrombosis and Haemostasis Poster
Research Impact Case Study Competition - runner up
(opens in a new window)AI_PREMie featured in RTE One in the "Science to the Rescue" show.
(opens in a new window)AI_PREMie project features in final #TheHealthPulse podcast of 2021 by @SASsoftware
(opens in a new window)Professor Maguire discusses AI_PREMie on #Allreland podcast
(opens in a new window)Article by Leaps
(opens in a new window)Article by Medicalxpress
2022
Professor Patricia Maguire interviewed on Newstalk The Pat Kenny Show discussing AI_PREMie project
(opens in a new window)AI_PREMie featured in RTE Changemakers
(opens in a new window)Microsoft recently published an article about AI_PREMie
Read more here:
AI_PREMie
The AI PREMie team, led by (opens in a new window)Professor Patricia Maguire from UCD School of Biomolecular and Biomedical Science, has been awarded €500,000 in recognition of the potential impact of their AI-powered risk stratification platform for preeclampsia. Also from the UCD ConwaySPHERE research group, the team includes Consultant Obstetrician and Gynaecologist (opens in a new window)Professor Mary Higgins and Consultant Haematologist and Full Clinical Professor Fionnuala Ní Áinle, UCD School of Medicine, and Dr Paulina Szklanna, UCD School of Biomolecular and Biomedical Science.
Preeclampsia (PET) is a condition of pregnancy that is difficult to diagnose and kills 50,000 mothers and 500,000 babies globally every year. At present delivery of the pre-term baby is the only treatment and the safest option for the mother. But pre-term delivery can lead to long-term neurodevelopmental problems and even death. ConwaySPHERE is working to develop a new diagnostic test called AI PREMie to better predict PET severity and help save the lives of both mothers and their babies. It is a risk stratification tool that identifies women with PET - and also how the condition will progress. Our AI PREMie tool assesses the pre-eclampsia risk based on circulating biomarkers in the plasma of pregnant mothers. This will give clinicians and other caregivers the opportunity to proactively plan pregnancies for at-risk mothers, giving a clearer understanding if planning for delivery is necessary or if the baby can stay in utero allowing for further development as every day in utero counts.
AI_PREMie Timeline
2017
(opens in a new window)Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early-onset preeclampsia.
2018
(opens in a new window)CAPE Study Results
(opens in a new window)Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.
(opens in a new window)The Hundred-Person Platelet Releasate Project.
2019
(opens in a new window)Science Foundation Ireland Future Innovator Prize
(opens in a new window)The platelet releasate in pregnancy and early-onset preeclampsia.
2020
(opens in a new window)Irish Tech news article
(opens in a new window)Article in Roller coaster
SAS Viya join the AI-PREMie team
2021
(opens in a new window)Winner of the NovaUCD Innovation of the Year Award 2021
(opens in a new window)Siliconrepublic article
(opens in a new window)Runner up SFI Future Innovator Artificial Intelligence (AI) for Societal Goo
(opens in a new window)Finalist of Analytics Institute Social Impact Award.
(opens in a new window)"Using platelets as little health sensors in our blood" - The Irish Times
(opens in a new window)"Using platelets as little health sensors in our blood" - Recruitment for Technology
(opens in a new window)Engineers Ireland Article
(opens in a new window)the pan Canadian thrombotic Research Network
(opens in a new window)the iPlacenta H2020 virtual conference
(opens in a new window)Teck Expert Article
(opens in a new window)Geant Article
(opens in a new window)HEAnet Article
(opens in a new window)Science Direct Article
(opens in a new window)University Observer Interview
(opens in a new window)AI_PREMie in 2021 AI_Awards Finalists
(opens in a new window)International Society on Thrombosis and Haemostasis Poster
Research Impact Case Study Competition - runner up
(opens in a new window)AI_PREMie featured in RTE One in the "Science to the Rescue" show.
(opens in a new window)AI_PREMie project features in final #TheHealthPulse podcast of 2021 by @SASsoftware
(opens in a new window)Professor Maguire discusses AI_PREMie on #Allreland podcast
(opens in a new window)Article by Leaps
(opens in a new window)Article by Medicalxpress
2022
Professor Patricia Maguire interviewed on Newstalk The Pat Kenny Show discussing AI_PREMie project
(opens in a new window)AI_PREMie featured in RTE Changemakers
(opens in a new window)Microsoft recently published an article about AI_PREMie
Read more here: