The UCD Conway SPHERE team (Lead RPO) has developed a new blood-based innovative diagnostics platform PALADINTM (PlAteLet bAsed DIagNostics) that captures the power of the platelet releasate and uses advanced proteomics methods, state-of-the-art equipment and artificial intelligence to uncover useful molecular diagnostics for chronic disease. PALADINTM addresses the unmet need for an easily accessible, minimally invasive source for high-quality specific molecular biomarkers in numerous diseases. In contrary to most often used biofluids with a very high dynamic range such as plasma or serum, PALADINTM harnesses the power of platelets which act as a natural ‘sieve’ and pick out important messages. Therefore, by analysing the platelet releasate the problem of highly abundant plasma proteins is resolved.