Publications

1. J.C. O'Donoghue and F.E. Freeman. "Make it STING: nanotechnological approaches for activating cGAS/STING as an immunomodulatory node in osteosarcoma", Frontiers in Immunology, 2024. DOI: (opens in a new window)10.3389/fimmu.2024.1403538.
2. S.W. Verbruggen, C.L. Freeman and F.E. Freeman. "Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells Escape from the Bone Marrow Microenvironment", Cancers, 2024. (opens in a new window)DOI: 10.3390/cancers16050889. 
3. F.E. Freeman, P. Dosta, L.C Shanley, N. Ramirez Tamez, C.J. Riojas Javelly, O.R. Mahon, D.J. Kelly and N. Artzi. “Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth”, Advanced Materials, 2023. (opens in a new window)DOI: 10.1002/adma.202207877.
4. D.C. Browe, R. Burdis, P.J. Díaz-Payno, F.E. Freeman, J. Nulty, C.T. Buckley, P.A.J. Brama, D.J. Kelly. “Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds” Materials Today Bio, 2022. (opens in a new window)DOI: 10.1016/j.mtbio.2022.100343.
5. R. Burdis, F. Chariyev-Prinz, D.C. Browe, F.E. Freeman, J. Nulty, E. McDonnell, K.F. Eichholz, B. Wang, P.A.J Brama, D.J. Kelly. “Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing”, Biomaterials, 2022. (opens in a new window)DOI: 10.1016/j.biomaterials.2022.121750.
6. K.F. Eichols, F.E. Freeman, P. Pitacco, J. Nulty, D.P. Ahern, R. Burdis, D.C. Browe, O. Garcia, D.A. Hoey and D.J. Kelly “Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects” Biofabrication, 2022. (opens in a new window)DOI: 10.1088/1758-5090/ac88a1
7. P.J. Díaz-Payno, D.C. Browe, F.E. Freeman, J. Nulty, R. Burdis, D.J. Kelly.”GREM1 suppresses hypertrophy of engineered cartilage in vitro but not bone formation in vivo”, Tissue Engineering Part A, 2022. (opens in a new window)DOI: 10.1089/ten.TEA.2021.0176.
8. D.C. Browe, P.J. Díaz-Payno, F.E. Freeman, R. Schipani, R. Burdis, D.P. Ahern, J. Nulty, S. Guler, L.D. Randall, C.T. Buckley, P.A.J. Brama, D.J. Kelly. “Bilayer Extracellular Matrix Derived Scaffolds with Tailored Pore Architecture for Osteochondral Defect Repair”, Acta Biomateriala, 2022. (opens in a new window)DOI: 10.1016/j.actbio.2022.03.009.
9. F.E. Freeman, R. Burdis, O.R. Mahon, D.J. Kelly and N. Artzi. “A spheroid model of early and late-stage osteosarcoma mimicking the divergent relationship between tumour elimination and bone regeneration”, Advanced Healthcare Materials, 2021. (opens in a new window)DOI: 10.1002/adhm.202101296.
10. F.E. Freeman, P. Pitacco, L.H.A. van Dommelen, J. Nulty, D.C. Browe, J.Y. Shin, E. Alsberg, D.J. Kelly. “Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects” Bio-protocol, 2021. (opens in a new window)DOI: 10.21769/BioProtoc.4219.
11. X. Barceló, S. Scheurer, R. Lakshmanan, C.J. Moran, D.J. Kelly, F.E. Freeman.”3D Bioprinting for Meniscus Tissue Engineering”, Journal of 3D Printing in Medicine, 2021. DOI: 10.2217/3dp-2021-0017.
12. F.E. Freeman, R. Burdis and D. J. Kelly, “Printing new bones: From print-and-implant devices to bioprinted bone organ precursors” Trends in Molecular Medicine, 2021. (opens in a new window)DOI: 10.1016/j.molmed.2021.05.001.
13. B Wang, P.J. Díaz-Payno, D.C. Browe, E. Freeman, J. Nulty, R. Burdis, D.J. Kelly, “Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues”, Acta Biomateriala, 2021. DOI: (opens in a new window)10.1016/j.actbio.2021.04.016.
14. J. Nulty, F.E. Freeman, D.C. Browe, R. Burdis, D.P. Ahern, P Pitacco, Y Bin Lee, E. Alsberg, D.J. Kelly, “3D bioprinting of prevascularised implants for the repair of critically-sized bone defects” Acta Biomateriala, 2021. (opens in a new window)DOI: 10.1016/j.actbio.2021.03.003.
15. F.E. Freeman, M.A. Brennan, D.C. Browe, A. Renaud, J. De Lima, D.J. Kelly, L.M. McNamara, P. Layrolle, “A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect”, Frontiers in Bioengineering and Biotechnology, 2020. (opens in a new window)DOI: 10.3389/fbioe.2020.00230.
16. F.E. Freeman, P. Pitacco, L.H.A. van Dommelen, J. Nulty, D.C. Browe, J.Y. Shin, E. Alsberg, D.J. Kelly, “3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration”, Science Advances, 2020. DOI: 10.1126/sciadv.abb5093
17. F.E. Freeman, D.C. Browe, J. Nulty, S. Von Euw, W.L. Grayson, D.J. Kelly, “Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering”, European Cells and Materials, 2019. (opens in a new window)DOI: 10.22203/eCM.v038a12.
18. T Gonzalez-Fernandez, S Rathan, C Hobbs, P Pitacco, F.E. Freeman, G.M. Cunniffe, N.J. Dunne, H.O. McCarthy, V Nicolosi, F.J. O'Brien, D.J. Kelly. “Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues”, Journal of Controlled Release, 2019. (opens in a new window)DOI: 10.1016/j.jconrel.2019.03.006.
19. F.E. Freeman, D.J. Kelly, Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues, Scientific Reports, 2017. (opens in a new window)DOI: 10.1038/s41598-017-17286-1.
20. F.E. Freeman, J. Schiavi, M.A. Brennan, P. Owen, P. Layrolle, and L.M. McNamara. “Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process can enhance the in vitro Mineralisation Potential of Human MSCs” Journal of Tissue Engineering Part A, 2017. (opens in a new window)DOI: 10.1089/ten.tea.2017.0052.
21. A.C. Daly, F.E. Freeman, T Fernandez Gonzalez, S.E. Critchley, J. Nulty, D.J. Kelly.”3D Bioprinting for Cartilage and Osteochondral Tissue Engineering” Advanced Healthcare Materials, 2017. (opens in a new window)DOI: 10.1002/adhm.201700298.
22. F.E. Freeman, L.M. McNamara, “Endochondral priming: a developmental engineering strategy for bone tissue regeneration”, Tissue Engineering Part B: Reviews, 2017. (opens in a new window)DOI: 10.1089/ten.teb.2016.0197.
23. F.E. Freeman, H.Y. Stevens, R.E. Guldberg, and L.M. McNamara. “Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template” Journal of Tissue Engineering Part A, 2016. (opens in a new window)DOI: 10.1089/ten.tea.2015.0339.
24. F.E. Freeman, A.B. Allen, H.Y. Stevens, R.E. Guldberg, L.M. McNamara, “Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo”, Stem Cell Research and Therapy, 2015. (opens in a new window)DOI: 10.1186/s13287-015-0210-2.
25. F.E. Freeman, M.G. Haugh, and L.M. McNamara “An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralisation potential of MSCs in vitro whilst also allowing for vessel formation.” Journal of Tissue Engineering Part A, 2015. (opens in a new window)DOI: 10.1089/ten.tea.2014.0249.
26. F.E. Freeman, M.G. Haugh, and L.M. McNamara “Investigation of Optimal Timing for Chondrogenic Priming of MSCs to Enhance Osteogenic Differentiation In Vitro as a Bone Tissue Engineering Strategy” Journal of Tissue Engineering and Regenerative Medicine, 2013. (opens in a new window)DOI: 10.1002/term.1793.