Using 3D bioprinting technologies to Create an Organ-on-Chip Device for Osteosarcoma and Its Surrounding Bone Microenvironment: A Platform for Drug Discovery and Therapeutic Innovation
Bioprinting has emerged as a revolutionary technology in the field of cancer research, offering a promising avenue for the development of complex tumour models. This cutting-edge technique allows scientists to create intricate 3D structures that closely mimic the microenvironment of tumours, including their heterogeneous cellular compositions and unique spatial arrangements. By precisely depositing live cells, extracellular matrices, and growth factors layer by layer, bioprinting enables the recreation of tumour models with remarkable accuracy. Our lab aims to use these advanced models not only to gain a better understanding of osteosarcoma tumour biology and behaviour but also to serve as invaluable platforms for drug testing, personalized medicine, and the exploration of novel therapeutic strategies. This work is funded by the Sarcoma Foundation of America Research Grant Agreement.
