Further Statistical Methodology for Extending the Scope of Angiogenic Factor Analysis
Speaker: Dr. Orlaith Burke, Oxford University
Time: 3.00PM
Date: Thursday 20th November 2014
Location: Seminar Room L504, 5th floor, Library Building
Abstract:
Circulating placental growth factor (PlGF) is a potential biomarker for preeclampsia. Prior studies show its limited precision in predicting or diagnosing preeclampsia, underscoring a common problem in biomarker data analyses in general - that large studies are needed to overcome clinical heterogeneity and to provide sufficient statistical power. Attaining such sample sizes often requires aggregation of cohorts. Different studies may use disparate platforms for laboratory analyses, complicating data merging. In our current work, we assessed whether PlGF concentrations could be merged across studies using inter-platform standardization.
This talk will cover the collection and standardisation of angiogenic factor data, the development of the merging algorithms used for these PlGF concentrations and the results of the first analysis from the Global CoLaboratory Angiogenic Factor Study. Additionally, the next stages of the study, both methodological and clinical, will be discussed.
Series: Statistics Seminar Series
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