How can we use high fidelity CA approach to help in planning more effective multi-dose radiotherapy?

Title: How can we use high fidelity CA approach to help in planning more effective multi-dose radiotherapy?

Speaker: Monika Piotrowska, Institute of Applied Mathematics and Mechanics, University of Warsaw

Date: Wednesday, 18th May 2016

Time: 3pm

Location: Room H1.51, Science Hub

Abstract:

During this talk I would like to, at least partially, answer that question. Multi-fraction radiotherapy protocols (fractional dose and timing) are currently a standard radiotherapy approach used in the clinic, however they are products of human selection based on received wisdom, physicians’ experience and intra-day patient timetabling rather then due to systemic study. Clearly, the potential treatment protocol space for a given total dose or treatment length is gigantic and far beyond the capacity of traditional experimental/medical methods to explore. Therefore, have developed a high fidelity numerical simulation of tumour growth to which we have added a single-, and then multi-, fraction irradiation and response module. With the fully developed and calibrated model we are then in a position to apply novel search methods over multi-fraction radiotherapy protocols to discover likely candidates to trial in the clinic.

Series: ACM