Systems Biology Ireland
Investigating new therapeutic approaches to disease, with a focus on cancer at a systems level. SBI use a combination of traditional wet-lab and computational modelling approaches to understand cellular signalling networks.
As pioneers in predictive modelling, precision medicine and bio-clinical informatics, UCD experts are pushing frontiers in translational research and the development of new therapeutics. Our researchers are bringing the lived experience of patients to the fore, in order to improve the quality of research and its relevance to society, and to positively impact patient outcomes.
Watch UCD Genomics Core Facility videoProfessor Des Higgins is the World number 1 in Sequence Alignment.
The UCD Conway Core Technologies programme is the most advanced analysis platform for life sciences and biomedical research in Ireland.
Prof Walter Kolch is World #2 in Precision Oncology and World #7 in Systems Medicine.
Systems Biology Ireland has secured over €61 million in funding for research on therapeutic approaches to disease.
Established in 2011 by UCD in partnership with TCD, DCU and Sligo IT, NIBRT is a global leader in the development of innovative technologies to advance biopharmaceutical manufacturing. This innovative collaboration between Industry, Government and Academia is an invaluable resource for the global biopharmaceutical industry, making transformative discoveries across multidisciplinary areas for the manufacturing of accessible and affordable medicines.
In a major collaborative work, an international team including UCD's Professor Vladimir Lobaskin, has discovered a new response mechanism specific to exposure to nanoparticles that is common to multiple species. By analysing a large collection of datasets, they have revealed an ancestral epigenetic mechanism of defence that explains how different species, from humans to simpler creatures, adapt to this type of exposure. Their paper published in Nature Nanotechnology is the first demonstration of the power of nanoinformatics, a new field of research extending the ideas from cheminformatics and bioinformatics.
A consortium of five Irish universities, six Irish charities and seven industrial partners with funding from SFI and industry, Precision Oncology Ireland is coordinated by Systems Biology Ireland. A core project is using samples from patients with neuroblastoma, a cancer affecting children aged five and under, to develop digital twin treatment models. These twins help doctors to better monitor individual patients, and devise optimal treatments which reduce patient exposure to toxins to the absolute minimum that is needed, and reduce severe side effects for children with cancer.
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