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Cell Biology Research
Group
Cancer Biology
The majority of cancer patients die because their tumour has metastasised
to other sites in the body. The major objective of this work is to
investigate the molecular mechanisms involved in tumour invasion
and metastasis. We have recently developed and extensively characterised
a cell line model of invasive human breast cancer and have used Affymetrix
gene arrays to identify new and better markers of metastatic disease.
We are also examining the cytotoxicity and anti-invasive activity
of novel 5-fluorouracil derivatives.
Large Scale Culture of Mammalian cells
One of the major challenges currently facing large-scale culture
of mammalian cells is the death of cells by apoptosis and the
subsequent termination of the process. The identification of
the onset of apoptosis in processes would have a major impact
on the development of techniques to extend the life-time and
thus productivity of the process. A novel and unique method for
monitoring these changes in the cell culture is presented by
the use of Focussed Beam Reflectance Measurement (FBRM).
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